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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
DYRK3
All Species:
50
Human Site:
Y375
Identified Species:
78.57
UniProt:
O43781
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43781
NP_001004023.1
588
65714
Y375
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
Chimpanzee
Pan troglodytes
XP_524527
588
65774
Y375
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
Rhesus Macaque
Macaca mulatta
XP_001086117
588
65769
Y375
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
Dog
Lupus familis
XP_537131
637
71340
Y425
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
Cat
Felis silvestris
Mouse
Mus musculus
Q922Y0
586
65553
Y374
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
Rat
Rattus norvegicus
Q4V8A3
586
65492
Y374
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511087
546
60615
Y334
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
Chicken
Gallus gallus
Q5ZIU3
526
59419
G325
V
I
L
G
A
R
Y
G
M
P
I
D
M
W
S
Frog
Xenopus laevis
NP_001088793
567
63329
Y355
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
Zebra Danio
Brachydanio rerio
NP_001108400
581
65351
Y366
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P83102
828
92722
Y442
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_001023207
817
89866
R617
S
S
C
F
D
D
Q
R
I
Y
T
Y
I
Q
S
Sea Urchin
Strong. purpuratus
XP_799140
561
63192
Y359
T
Y
I
Q
S
R
F
Y
R
A
P
E
V
I
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51566
467
54180
L275
D
G
S
Y
F
K
N
L
P
K
S
S
A
I
K
Baker's Yeast
Sacchar. cerevisiae
P14680
807
91227
Y536
T
Y
I
Q
S
R
F
Y
R
A
P
E
I
I
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
98.8
85.7
N.A.
89.6
90.8
N.A.
57.9
59
65.3
63.4
N.A.
39
N.A.
40.5
54.7
Protein Similarity:
100
99.4
99.4
88.8
N.A.
93.5
94.2
N.A.
70.7
71.9
77.8
76.6
N.A.
50.9
N.A.
52.5
68.3
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
6.6
93.3
93.3
N.A.
93.3
N.A.
6.6
93.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
40
100
100
N.A.
100
N.A.
13.3
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
22.2
26.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
41
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
100
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
100
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
7
0
0
0
0
80
0
0
7
0
0
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
0
0
0
7
7
0
0
0
0
0
7
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
80
0
0
0
% E
% Phe:
0
0
0
7
7
0
80
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
0
7
0
0
0
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
7
80
0
0
0
0
0
7
0
7
0
54
87
0
% I
% Lys:
0
0
0
0
0
7
0
0
0
7
0
0
0
0
7
% K
% Leu:
0
0
7
0
0
0
0
7
0
0
0
0
0
0
80
% L
% Met:
0
0
0
0
0
0
0
0
7
0
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
7
7
80
0
0
0
0
% P
% Gln:
0
0
0
80
0
0
7
0
0
0
0
0
0
7
0
% Q
% Arg:
0
0
0
0
0
87
0
7
80
0
0
0
0
0
0
% R
% Ser:
7
7
7
0
80
0
0
0
0
0
7
7
0
0
14
% S
% Thr:
80
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% T
% Val:
7
0
0
0
0
0
0
0
0
0
0
0
34
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% W
% Tyr:
0
80
0
7
0
0
7
80
0
7
0
7
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _